Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility

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Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility.

Application of hydrodynamic mild shear stress to adherent Dictyostelium discoideum vegetative cells triggers active actin cytoskeleton remodeling resulting in net cell movement along the flow. The average cell speed is strongly stimulated by external calcium (Ca2+, K50%=22 microM), but the directionality of the movement is almost unaffected. This calcium concentration is ten times higher than t...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2005

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.02461